The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2020
Filed:
Sep. 26, 2018
Applicant:
Nucana Plc, Edinburgh, GB;
Inventors:
Hugh Griffith, Edinburgh, GB;
Gordon Kennovin, Edinburgh, GB;
Assignee:
NuCana plc, Edinburgh, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7068 (2006.01); A61K 47/16 (2006.01); A61K 9/00 (2006.01); A61K 47/20 (2006.01); A61K 47/22 (2006.01); A61K 9/08 (2006.01); A61K 47/54 (2017.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); A61K 47/44 (2017.01);
U.S. Cl.
CPC ...
A61K 31/7068 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 47/16 (2013.01); A61K 47/18 (2013.01); A61K 47/20 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61K 47/44 (2013.01); A61K 47/548 (2017.08);
Abstract
This invention relates to pharmaceutical formulations of gemcitabine-[phenyl-(benzoxy-L-alaninyl)]-phosphate, a monophosphate derivative of the well-known oncology drug gemcitabine. In particular, the invention relates to formulations which comprise a polar aprotic solvent, preferably dimethyl acetamide (DMA). Formulations comprising this solvent provide therapeutically effective treatments of gemcitabine-[phenyl-(benzoxy-L-alaninyl)]-phosphate. The invention also relates to methods of using said formulations and kits comprising said formulations.