The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2020
Filed:
Feb. 19, 2018
Case Western Reserve University, Cleveland, OH (US);
Anant Madabhushi, Shaker Heights, OH (US);
Cheng Lu, Cleveland Heights, OH (US);
Case Western Reserve University, Cleveland, OH (US);
Abstract
Embodiments include apparatus for predicting cancer recurrence based on local co-occurrence of cell morphology (LoCoM). The apparatus includes image acquisition circuitry that identifies and segments at least one cellular nucleus represented in an image of a region of tissue demonstrating cancerous pathology; local nuclei graph (LNG) circuitry that constructs an LNG based on the at least one cellular nucleus, and computes a set of nuclear morphology features for a nucleus represented in the LNG; LoCoM circuitry that constructs a co-occurrence matrix based on the nuclear morphology features, computes a set of LoCoM features for the co-occurrence matrix, and computes a LoCoM signature for the image based on the set of LoCoM features; progression circuitry that generates a probability that the region of tissue will experience cancer progression based on the LoCoM signature, and classifies the region of tissue as a progressor or non-progressor based on the probability.