The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 22, 2020

Filed:

Aug. 07, 2017
Applicant:

Yale University, New Haven, CT (US);

Inventor:

Hur Koser, Branford, CT (US);

Assignee:

YALE UNIVERSITY, New Haven, CT (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 15/10 (2006.01); B03C 1/32 (2006.01); B03C 1/023 (2006.01); B03C 1/23 (2006.01); B03C 1/28 (2006.01); B03C 1/253 (2006.01); B01L 3/00 (2006.01); C12M 1/00 (2006.01); C12N 13/00 (2006.01); G01N 15/00 (2006.01);
U.S. Cl.
CPC ...
G01N 15/1056 (2013.01); B01L 3/50273 (2013.01); B01L 3/502715 (2013.01); B01L 3/502761 (2013.01); B03C 1/023 (2013.01); B03C 1/23 (2013.01); B03C 1/253 (2013.01); B03C 1/288 (2013.01); B03C 1/32 (2013.01); C12M 47/04 (2013.01); C12N 13/00 (2013.01); B01L 2200/0636 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0848 (2013.01); B03C 2201/18 (2013.01); B03C 2201/24 (2013.01); B03C 2201/26 (2013.01); G01N 2015/0065 (2013.01); G01N 2015/1006 (2013.01); G01N 2015/1081 (2013.01);
Abstract

A device for separating a sample of cells suspended in a bio-compatible ferrofluid is described. The device includes a microfluidic channel having a sample inlet, at least one output, and a length between the sample inlet and the at least one output, wherein a sample can be added to the sample inlet and flow along the length to the at least one outlet. The device includes a plurality of electrodes, wherein the microfluidic channel length transverses the plurality of electrodes, and further includes a power source for applying a current to the plurality of electrodes to create a magnetic field pattern along the length of the microfluidic channel. The present invention also includes a method for separating at least one cell type. The method includes the steps of suspending cells in a bio-compatible ferrofluid to form a sample, passing the sample through a microfluidic channel that transverses a plurality of electrodes, applying a current to the plurality of electrodes to create a magnetic field pattern along the length of the microfluidic channel, and sorting the cells into at least one output channel based on a variation of at least one of cell size, shape and elasticity.


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