The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 22, 2020

Filed:

Mar. 09, 2016
Applicants:

University of Kentucky Research Foundation, Lexington, KY (US);

Daxiang Cui, Shanghai, CN;

Chunlei Zhang, Shanghai, CN;

Inventors:

Peixuan Guo, Columbus, OH (US);

Daxiang Cui, Shanghai, CN;

Dan Shu, Columbus, OH (US);

Yi Shu, Lexington, KY (US);

Chunlei Zhang, Shanghai, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C07H 21/04 (2006.01); C12N 15/11 (2006.01); C12N 15/115 (2010.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61P 35/00 (2018.01); C07H 21/04 (2013.01); C12N 15/111 (2013.01); C12N 15/115 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/3519 (2013.01); C12N 2310/52 (2013.01); C12N 2320/32 (2013.01);
Abstract

The presently-disclosed subject matter relates to RNA-based composition and method to treat gastric cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure and composition containing a multiple branched RNA nanoparticle, a gastric cancer targeting module, and an effective amount of a therapeutic agent. Further, the presently disclosed subject matter relates to a method of using the RNA nanoparticle composition to treat gastric cancer in a subject having or at risk of having gastric cancer.


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