The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2020
Filed:
Aug. 08, 2019
Vividion Therapeutics, Inc., San Diego, CA (US);
The Scripps Research Institute, La Jolla, CA (US);
David Weinstein, San Diego, CA (US);
Benjamin F. Cravatt, La Jolla, CA (US);
Matthew Patricelli, San Diego, CA (US);
Dean Stamos, San Diego, CA (US);
Gabe Simon, San Diego, CA (US);
Benjamin Horning, San Diego, CA (US);
Ekaterina Vinogradova, San Diego, CA (US);
Brian Nordin, San Diego, CA (US);
Kristen Baltgalvis, San Diego, CA (US);
Todd Kinsella, San Diego, CA (US);
VIVIDION THERAPEUTICS, INC., San Diego, CA (US);
THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);
Abstract
Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO:2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO:2 or 3.