The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 22, 2020
Filed:
Mar. 07, 2017
Applicants:
The Regents of the University of Michigan, Ann Arbor, MI (US);
UniversitĂ Degli Studi Di Sassari, Sassari, IT;
Inventors:
Nouri Neamati, Ann Arbor, MI (US);
Mario Sechi, Sassari, IT;
Assignees:
The Regents of the University of Michigan, Ann Arbor, MI (US);
UNIVERSITA DEGLI STUDI DI SASSARI, Sassari, IT;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/74 (2006.01); A61P 35/00 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); C07D 471/04 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); A61K 31/517 (2006.01);
U.S. Cl.
CPC ...
C07D 239/74 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01);
Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazolinedione structure which function as reactive oxygen species (ROS) inducers and inhibitors of mitochondrial activity within cancer cells (e.g., pancreatic cancer cells), and their use as therapeutics for the treatment of cancer (e.g., pancreatic cancer) and other diseases.