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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10781180 B1

PDFFull Text
Date of Patent:
Sep. 22, 2020

Filed:

Nov. 01, 2018

3-phenyl-pyrazole derivatives as modulators of the 5-htserotonin receptor useful for the treatment of disorders related thereto

Applicant:

Arena Pharmaceuticals, Inc., San Diego, CA (US);

Inventors:

Bradley Teegarden, San Diego, CA (US);

Yifeng Xiong, San Diego, CA (US);

Sonja Strah-Pleynet, Newton, MA (US);

Honnappa Jayakumar, San Diego, CA (US);

Peter I. Dosa, San Diego, CA (US);

Konrad Feichtinger, San Diego, CA (US);

Martin Casper, San Diego, CA (US);

Juerg Lehmann, San Diego, CA (US);

Robert M. Jones, San Diego, CA (US);

David J. Unett, San Diego, CA (US);

Jin Sun Karoline Choi, San Diego, CA (US);

Assignee:

Arena Pharmaceuticals, Inc., San Diego, CA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 231/12 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 487/08 (2006.01); C07D 231/16 (2006.01); C07D 417/12 (2006.01); A61K 31/5377 (2006.01); C07D 413/10 (2006.01);
U.S. Cl.
CPC ...
C07D 231/12 (2013.01); A61K 31/5377 (2013.01); C07D 231/16 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C07D 487/08 (2013.01);
Abstract

The present invention relates to certain 3-phenyl-pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HTserotonin receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of platelet aggregation, coronary artery disease, myocardial infarction, transient ischemic attack, angina, stroke, atrial fibrillation, reducing the risk of blood clot formation, asthma or symptoms thereof, agitation or a symptom, behavioral disorders, drug induced psychosis, excitative psychosis, Gilles de la Tourette's syndrome, manic disorder, organic or NOS psychosis, psychotic disorder, psychosis, acute schizophrenia, chronic schizophrenia, NOS schizophrenia and related disorders, and sleep disorders, sleep disorders, diabetic-related disorders, progressive multifocal leukoencephalopathy and the like. The present invention also relates to the methods for the treatment of 5-HTserotonin receptor mediated disorders in combination with other pharmaceutical agents administered separately or together.

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