The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 22, 2020

Filed:

Aug. 07, 2015
Applicants:

The Regents of the University of California, Oakland, CA (US);

Nippon Zoki Pharmaceutical Co., Ltd., Osaka, JP;

Inventors:

Ekihiro Seki, San Diego, CA (US);

Koichi Masuda, San Diego, CA (US);

Mitsuru Naiki, Hyogo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/36 (2015.01); A61K 9/00 (2006.01); A61K 35/76 (2015.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/36 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 35/76 (2013.01); C12N 7/00 (2013.01); A61K 2039/515 (2013.01); A61K 2039/58 (2013.01); C12N 2710/24133 (2013.01);
Abstract

An object of the present invention is to provide a protective method for liver comprising the administration of an extract from inflamed tissues inoculated with vaccinia virus to a patient who needs the treatment and to provide a liver protective agent, etc. where such an extract is an active ingredient. In the present invention, it has been recognized that, in hepatocytes, activation of NF-B, expression of NF-B target genes, activation of JNK, apoptosis and fat accumulation can be inhibited or suppressed. The agent containing the extract as an active ingredient is a drug exhibiting less adverse action and high safety. Accordingly, the present invention provides very useful protective method for liver and liver protecting agent.


Find Patent Forward Citations

Loading…