The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 15, 2020

Filed:

Oct. 14, 2014
Applicants:

Nova Southeastern University, Fort Lauderdale, FL (US);

University of Miami, Miami, FL (US);

University of Alberta, Tec Edmonton, Edmonton, Alberta, CA (US);

Inventors:

Mary Ann Fletcher, Miami, FL (US);

Gordon Broderick, Edmonton, Alberta, CA (US);

Nancy Klimas, Fort Lauderdale, FL (US);

Zachary Barnes, Miami, FL (US);

Assignees:

Nova Southeastern University, Fort Lauderdale, FL (US);

University of Miami, Miami, FL (US);

University of Alberta, TEC Edmonton, Edmonton, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G16B 5/00 (2019.01); G16B 40/00 (2019.01); A61K 38/20 (2006.01);
U.S. Cl.
CPC ...
G16B 5/00 (2019.02); A61K 38/2086 (2013.01); G16B 40/00 (2019.02);
Abstract

A general method of analyzing immune signaling networks for identification of potential therapeutic targets in complex, chronic medical disorders is described. The disclosure provides the CD3−/CD56+ natural killer (NK) cell population as a potential therapeutic target in the clinically-overlapping disorders Gulf War Illness (GWI) and Myalg Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The disclosure also provides a method for improving or restoring Natural Killer (NK) cell function by stimulating the NK cells with interleukin-15 (IL-15).


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