The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Jun. 25, 2018
Zhejiang Nhu Company Ltd., Hangzhou, Zhejiang Province, CN;
Zhejiang University, Hangzhou, Zhejiang Province, CN;
Heilongjiang Nhu Biotechnology Company Ltd., Sui Hua, Hei Longjiang Province, CN;
Shangyu Nhu Biological Chemical Co., Ltd., Shaoxing, Zhejiang Province, CN;
Shenfeng Yuan, Hangzhou, CN;
Hongwei Yu, Hangzhou, CN;
Zhaofeng Chen, Shaoxing, CN;
Yongqiang Zhu, Shaoxing, CN;
Yi Min, Shaoxing, CN;
Yong Li, Shaoxing, CN;
Baishan Hu, Shaoxing, CN;
Guisheng Qiu, Shaoxing, CN;
Kai Yu, Shaoxing, CN;
ZHEJIANG NHU COMPANY LTD., Shaoxing, CN;
ZHEJIANG UNIVERSITY, Hangzhou, CN;
HEILONGJIANG NHU BIOTECHNOLOGY COMPANY LTD., Sui Hua, CN;
SHANGYU NHU BIOLOGICAL CHEMICAL CO., LTD., Shaoxing, CN;
Abstract
The present application relates to a method for fermentative production of oxidized coenzyme Q10 and high-content oxidized coenzyme Q10 prepared therefrom. For the method for fermentative production of oxidized coenzyme Q10, in a fermentation process of a production strain, the oxidation-reduction potential (ORP) of a fermentation broth is controlled to be −50 to 300 Mv, and preferably the oxidation-reduction potential (ORP) of the fermentation broth is controlled to be 50 to 200 mV. By controlling the ORP of the fermentation broth, the method for fermentative production of oxidized coenzyme Q10 enables the oxidized coenzyme Q10 content in the coenzyme Q10 produced by microorganisms to reach 96% or more, and the product is substantially composed of a single component, which makes post-treatment more convenient. Oxidized coenzyme Q10 is more stable than reduced coenzyme Q10, and as compared with the coenzyme Q10 obtained by fermentative production in the prior art, high-content oxidized coenzyme Q10 degrades in a less amount in organisms. In addition, the fermentation method of the present application has a high potency.