The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Dec. 23, 2015
Massachusetts Institute of Technology, Cambridge, MA (US);
European Molecular Biology Laboratory, Heidelberg, DE;
Manolis Kellis, Brookline, MA (US);
Melina Christine Claussnitzer, Somerville, MA (US);
Jan Korbel, Heidelberg, DE;
MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Cambridge, MA (US);
EUROPEAN MOLECULAR BIOLOGY LABORATORY, Heidelberg, DE;
Abstract
Provided herein is a pathway for adipocyte energy consumption regulation involving ARID5B, genetic variant rs1421085, IRX3, and IRX5. Compositions and methods for modulating the pathway in vitro and in vivo for anti-cachectic and anti-obesity effects are provided. Methods of identifying subjects at risk of developing a disorder mediated by a dysregulation of the energy consumption pathway are also provided.