The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Jul. 12, 2017
Fidia Farmaceutici S.p.a., Abano Terme, IT;
Susanna Vaccaro, Abano Terme, IT;
Michele Caputo, Abano Terme, IT;
Christian Cuppari, Abano Terme, IT;
Giovanni Gennari, Abano Terme, IT;
FIDIA FARMACEUTICI S.P.A., Abano Terme, IT;
Abstract
The present invention claims a novel process for the production and purification of microbial collagenase (Microbial Collagenase EC 3.4.24.3) produced by the non-pathogenic aerobic bacteriumchemovar.(NCIMB Number: 11038, synonym LMG 3418, hereinafter called), which said process provides high production levels of collagenase with a stable, reproducible, cheap fermentation process. The collagenase produced fromaccording to the process described herein also presents a specific activity superior to that of other microbial collagenases, is stable in aqueous solution, and can be frozen without significant damage. A further subject of the present invention is pharmaceutical compositions containing collagenase obtained according to the production and purification process described, for the purpose of therapeutic treatment of disorders characterised by collagen accumulation or for the treatment of blemishes/imperfections that benefit from reducing local collagen accumulations.