The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 15, 2020

Filed:

Dec. 04, 2015
Applicant:

Taurus Biosciences, Llc, San Diego, CA (US);

Inventors:

Vaughn Smider, San Diego, CA (US);

James Graziano, San Diego, CA (US);

Helen Hongyuan Mao, San Diego, CA (US);

Byeong Doo Song, Kangwon, KR;

Tyson Chase, San Diego, CA (US);

Omar Bazirgan, San Diego, CA (US);

Assignee:

Taurus Biosciences, LLC, San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 40/10 (2006.01); C07K 16/22 (2006.01); C40B 50/08 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C40B 40/08 (2006.01); C07K 16/32 (2006.01); C12N 15/10 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); C07K 16/00 (2013.01); C07K 16/18 (2013.01); C07K 16/28 (2013.01); C07K 16/2863 (2013.01); C07K 16/2869 (2013.01); C07K 16/2884 (2013.01); C07K 16/2887 (2013.01); C07K 16/32 (2013.01); C12N 15/1037 (2013.01); C40B 40/08 (2013.01); C40B 50/08 (2013.01); G01N 33/6845 (2013.01); C07K 2317/14 (2013.01); C07K 2317/24 (2013.01); C07K 2317/51 (2013.01); C07K 2317/515 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2317/73 (2013.01); C07K 2317/74 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C40B 40/10 (2013.01);
Abstract

Methods for making a combinatorial antibody library from human germline segments are provided. Also provided are libraries of nucleic acid molecules compiled from germline segments encoding VL chains and libraries of nucleic acid molecules encoding VH chains, and resulting antibody libraries. The libraries are provided as addressable libraries. Methods for screening antibody libraries against a target protein antigen, and the identified or selected antibodies are provided.


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