The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Dec. 12, 2016
Applicant:
Glaxosmithkline Biologicals, SA, Rixensart, BE;
Inventors:
Helene G. Bazin-Lee, Hamilton, MT (US);
Laura S. Bess, Hamilton, MT (US);
David A. Johnson, Hamilton, NC (US);
Assignee:
GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07F 9/10 (2006.01); C07F 9/6558 (2006.01); C07F 9/6561 (2006.01);
U.S. Cl.
CPC ...
C07F 9/65583 (2013.01); C07F 9/10 (2013.01); C07F 9/65616 (2013.01);
Abstract
The present invention relates to a process for phospholipidation of imidazoquinolines and oxoadenines. More particularly, the present invention relates to a high-yielding and scalable procedure for the phospholipidation of imidazoquinolines and oxoadenines which obviates the need to isolate unstable phosphoramidite intermediates. This process may be used for the phospholipidation of toll-like receptor 7 (TLR7)—active and toll-like receptor (TLR8)—active imidazoquinolines and oxoadenines.