The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Apr. 26, 2016
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Ravi K. Amaravadi, Media, PA (US);
Jeffrey Winkler, Wynnewood, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 219/12 (2006.01); A61K 31/473 (2006.01); A61K 45/06 (2006.01); A61K 31/7068 (2006.01); A61P 37/00 (2006.01); A61P 17/00 (2006.01); A61P 19/02 (2006.01); A61P 33/06 (2006.01); A61P 35/04 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 219/12 (2013.01); A61K 31/473 (2013.01); A61K 31/7068 (2013.01); A61K 45/06 (2013.01); A61P 17/00 (2018.01); A61P 19/02 (2018.01); A61P 33/06 (2018.01); A61P 35/00 (2018.01); A61P 35/04 (2018.01); A61P 37/00 (2018.01); Y02A 50/411 (2018.01);
Abstract
The invention provides dimeric quinacrine derivatives and related compounds and compositions, methods of treatment and syntheses. The novel compounds exhibit unexpected anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.