The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Oct. 23, 2017
Modernatx, Inc., Cambridge, MA (US);
Stephane Bancel, Cambridge, MA (US);
Tirtha Chakraborty, Medford, MA (US);
Antonin De Fougerolles, Waterloo, BE;
Sayda M. Elbashir, Cambridge, MA (US);
Matthias John, Cambridge, MA (US);
Atanu Roy, Stoneham, MA (US);
Susan Whoriskey, Belmont, MA (US);
Kristy M. Wood, Wellesley, MA (US);
Paul Hatala, Charlestown, MA (US);
Jason P. Schrum, Philadelphia, PA (US);
Kenechi Ejebe, New York, NY (US);
Jeff Lynn Ellsworth, Lexington, MA (US);
Justin Guild, Framingham, MA (US);
ModernaTX, Inc., Cambridge, MA (US);
Abstract
The invention relates to a pharmaceutical composition including a plurality of lipid nanoparticles having a mean particle size of between 80 nm and 160 nm and containing an mRNA encoding a polypeptide. The lipid nanoparticles include a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid. The mRNA contains a 5'-cap, 5′-UTR, a 3′-UTR, and a poly-A region with at least 100 nucleotides.