The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Nov. 18, 2014
Applicants:
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Anthony Rosenzweig, Newton, MA (US);
Vassilios J. Bezzerides, Brookline, MA (US);
Assignees:
Beth Israel Deaconess Medical Center, Inc., Boston, MA (US);
Children's Medical Center Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07K 14/47 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 48/0058 (2013.01); A61K 48/0075 (2013.01); C07K 14/47 (2013.01); C12N 15/86 (2013.01); C12N 2710/00041 (2013.01); C12N 2710/10343 (2013.01); C12N 2750/14143 (2013.01); C12N 2830/006 (2013.01); C12N 2830/008 (2013.01);
Abstract
The invention relates to the use of a CITED4 polypeptide and/or a microRNA-222 or precursor (e.g., pre-miR-222) or mimic thereof, for treating a cardiovascular disease or pathological condition, such as heart failure, myocardial infarction, and for promoting post-myocardial infarction cardiac remodeling in heart tissue.