The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Jun. 22, 2018
Mersana Therapeutics, Inc., Cambridge, MA (US);
Venu Reddy Gurijala, Lancaster, MA (US);
Satyanarayan Reddy Bollu, Plainville, MA (US);
Jacques Leblanc, Millbury, MA (US);
Timothy B. Lowinger, Carlisle, MA (US);
Dennis McGillicuddy, Reading, MA (US);
Mao Yin, Needham, MA (US);
Aleksandr V. Yurkovetskiy, Littleton, MA (US);
Mersana Therpeutics, Inc., Cambridge, MA (US);
Abstract
The disclosure provides methods of synthesis of polymeric scaffolds, e.g., those useful for conjugating with a protein based recognition-molecule (PBRM) to form PBRM-polymer-drug conjugates, and PBRM-polymer-drug conjugates thereof. The methods according to the disclosure allow for large-scale preparation of polymeric scaffolds having a high purity. In some embodiments, the methods according to the disclosure also allow for the preparation of scaffolds and conjugates thereof in better yield than previously used methods for preparing same. Also disclosed are methods of purifying polymeric scaffolds.