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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10772942 B1

PDFFull Text
Date of Patent:
Sep. 15, 2020

Filed:

Mar. 24, 2015

Lyophilized factor ix formulations

Applicant:

Bioverativ Therapeutics Inc., Waltham, MA (US);

Inventors:

Brian M. Thome, Boston, MA (US);

Cherie Parkhurst-Lang, Londonderry, NH (US);

Brandon W. Leveille, Berwick, MA (US);

Assignee:

Bioverativ Therapeutics Inc., Waltham, MA (US);

Attorneys:

Lathrop GPM LLP

James H. Velema, Esq.

Primary Examiner:

Michael Szperka

Int. Cl.
CPC ...
A61K 38/36 (2006.01); A61K 38/48 (2006.01); F26B 5/06 (2006.01); A61K 47/18 (2017.01); A61K 9/00 (2006.01); A61K 9/19 (2006.01); A61K 47/22 (2006.01); A61K 47/26 (2006.01);
U.S. Cl.
CPC ...
A61K 38/4846 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 47/183 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); C12Y 304/21022 (2013.01); F26B 5/06 (2013.01);
Abstract

The present invention provides, among other things, pre-lyophilization formulations, reconstituted formulations, and lyophilate powder compositions comprising a Factor IX (FIX) polypeptide. The present invention also provides lyophilization methods for producing lyophilate powder comprising a FIX polypeptide. The present invention is directed to a pre-lyophilization formulation comprising: (a) a Factor IX (FIX) polypeptide having FIX coagulation activity; (b) a buffering agent; (c) a stabilizing agent; (d) a bulking agent; and (e) a surfactant, wherein the formulation has a fill volume of less than about 5 mL, and wherein each of (a)-(e) are at an amount per vial (mg/vial) sufficient to allow (1) improved stability of the FIX polypeptide when lyophilized.

Find Patent Forward Citations

Thome, Brian. (2020). Lyophilized factor ix formulations (U.S. Patent No. 10772942). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10772942

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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