The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
Jan. 13, 2016
Applicant:
Yale University, New Haven, CT (US);
Inventors:
Assignee:
Yale University, New Haven, CT (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/45 (2006.01); A61K 31/7088 (2006.01); C12N 15/113 (2010.01); C12N 9/12 (2006.01); A61K 38/17 (2006.01);
U.S. Cl.
CPC ...
A61K 38/45 (2013.01); A61K 31/7088 (2013.01); A61K 38/1709 (2013.01); C12N 9/12 (2013.01); C12Y 207/11024 (2013.01);
Abstract
The present invention includes methods and compositions for increasing longevity of a cell and increasing cellular resistance to stress. In certain embodiments, the invention includes a method to induce gene expression of a homolog of Pachytene Checkpoint 2 (pch-2) or bmk-1 gene. The present invention also includes methods to treat oxidative stress or induce cellular death or apoptosis by administering a composition comprising a modulator of pch-2 or bmk-1 homolog gene expression.