The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 15, 2020
Filed:
May. 05, 2016
Applicant:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Inventors:
Mark R. Kelley, Zionsville, IN (US);
Melissa Fishel, Fishers, IN (US);
Assignee:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/192 (2006.01); A61K 45/06 (2006.01); A61K 31/519 (2006.01); A61K 31/63 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/192 (2013.01); A61K 31/519 (2013.01); A61K 31/63 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61K 2300/00 (2013.01);
Abstract
Methods for targeting apurinic/apyrimidinic endonuclease1/redox effector factor 1 (APE1/Ref-1) are disclosed. More particularly, methods for inhibiting APE1/Ref-1 and hypoxia-mediated signaling for decreasing survival and invasion of tumor cells exposed to hypoxic conditions are disclosed.