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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10772858 B1

PDFFull Text
Date of Patent:
Sep. 15, 2020

Filed:

May. 02, 2016

Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors

Applicants:

Georgia State University Research Foundation, Atlanta, GA (US);

Emory University, Atlanta, GA (US);

Inventors:

Binghe Wang, Marietta, GA (US);

Erwin Van Meir, Tucker, GA (US);

Jalisa Holmes Ferguson, Chamblee, GA (US);

Stefan Kaluz, Atlanta, GA (US);

Xingyue Ji, Atlanta, GA (US);

Assignees:

GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC., Atlanta, GA (US);

EMORY UNIVERSITY, Atlanta, GA (US);

Attorney:

Kilpatrick Townsend & Stockton LLP

Primary Examiner:

Craig D Ricci

Assistant Examiner:

Janet L Coppins

Int. Cl.
CPC ...
A61K 31/192 (2006.01); A61K 31/495 (2006.01); A01N 31/04 (2006.01); A61K 31/7068 (2006.01); A61K 31/536 (2006.01); A61K 31/435 (2006.01); A61K 31/175 (2006.01); A61K 31/17 (2006.01); A61K 31/475 (2006.01); A61K 31/166 (2006.01); A61P 35/00 (2006.01); A61K 31/085 (2006.01); A61K 31/09 (2006.01); A61K 31/341 (2006.01); A61K 31/343 (2006.01); A61K 31/351 (2006.01); A61K 31/352 (2006.01); A61K 31/357 (2006.01); A61K 31/381 (2006.01); A61K 31/397 (2006.01); A61K 31/40 (2006.01); A61K 31/421 (2006.01); A61K 31/436 (2006.01); A61K 31/443 (2006.01); A61K 31/444 (2006.01); A61K 31/445 (2006.01); A61K 31/5375 (2006.01); A61K 31/538 (2006.01); A61K 45/06 (2006.01); C07C 43/295 (2006.01); C07D 205/04 (2006.01); C07D 207/12 (2006.01); C07D 211/46 (2006.01); C07D 213/65 (2006.01); C07D 263/32 (2006.01); C07D 265/36 (2006.01); C07D 295/096 (2006.01); C07D 307/12 (2006.01); C07D 307/20 (2006.01); C07D 307/79 (2006.01); C07D 309/10 (2006.01); C07D 311/70 (2006.01); C07D 319/16 (2006.01); C07D 333/54 (2006.01); C07D 405/12 (2006.01); C07D 491/052 (2006.01);
U.S. Cl.
CPC ...
A61K 31/192 (2013.01); A01N 31/04 (2013.01); A61K 31/085 (2013.01); A61K 31/09 (2013.01); A61K 31/166 (2013.01); A61K 31/17 (2013.01); A61K 31/175 (2013.01); A61K 31/341 (2013.01); A61K 31/343 (2013.01); A61K 31/351 (2013.01); A61K 31/352 (2013.01); A61K 31/357 (2013.01); A61K 31/381 (2013.01); A61K 31/397 (2013.01); A61K 31/40 (2013.01); A61K 31/421 (2013.01); A61K 31/435 (2013.01); A61K 31/436 (2013.01); A61K 31/443 (2013.01); A61K 31/444 (2013.01); A61K 31/445 (2013.01); A61K 31/475 (2013.01); A61K 31/495 (2013.01); A61K 31/536 (2013.01); A61K 31/538 (2013.01); A61K 31/5375 (2013.01); A61K 31/7068 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07C 43/295 (2013.01); C07D 205/04 (2013.01); C07D 207/12 (2013.01); C07D 211/46 (2013.01); C07D 213/65 (2013.01); C07D 263/32 (2013.01); C07D 265/36 (2013.01); C07D 295/096 (2013.01); C07D 307/12 (2013.01); C07D 307/20 (2013.01); C07D 307/79 (2013.01); C07D 309/10 (2013.01); C07D 311/70 (2013.01); C07D 319/16 (2013.01); C07D 333/54 (2013.01); C07D 405/12 (2013.01); C07D 491/052 (2013.01);
Abstract

This disclosure relates to benzhydrol derivatives for managing conditions related to the Hypoxia Inducible Factor (HIF) pathway such as uses in treating cancer. In certain embodiment, the disclosure contemplates compounds and pharmaceutical compositions. In certain embodiment, the disclosure contemplates compounds disclosed herein as prodrugs, optionally substituted with one or more substituents, derivatives, or salts thereof.

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