The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 15, 2020

Filed:

Feb. 21, 2019
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Gary Gerstenblith, Reisterstown, MD (US);

Jason Benkoski, Ellicott City, MD (US);

George Coles, Baltimore, MD (US);

Chao-Wei Hwang, Ellicott City, MD (US);

Peter Johnston, Baltimore, MD (US);

Gordon Tomaselli, Lutherville, MD (US);

Robert G. Weiss, Hunt Valley, MD (US);

Steven P. Schulman, Reisterstown, MD (US);

Jeffrey A. Brinker, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61F 2/02 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01); A61K 35/545 (2015.01); A61L 29/00 (2006.01); A61L 29/16 (2006.01); C12N 5/0775 (2010.01); A61K 35/28 (2015.01); A61K 9/00 (2006.01); A61L 29/14 (2006.01); A61L 31/10 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); A61L 27/16 (2006.01); A61L 27/28 (2006.01); A61L 27/56 (2006.01);
U.S. Cl.
CPC ...
A61F 2/022 (2013.01); A61K 9/0024 (2013.01); A61K 35/28 (2013.01); A61K 35/545 (2013.01); A61L 27/16 (2013.01); A61L 27/28 (2013.01); A61L 27/3834 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 29/00 (2013.01); A61L 29/005 (2013.01); A61L 29/146 (2013.01); A61L 29/16 (2013.01); A61L 31/10 (2013.01); A61L 31/145 (2013.01); A61L 31/146 (2013.01); A61L 31/16 (2013.01); C12N 5/0663 (2013.01); A61L 2300/30 (2013.01); A61L 2300/42 (2013.01); A61L 2300/64 (2013.01); A61L 2430/20 (2013.01); C12N 2533/30 (2013.01);
Abstract

A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.


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