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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10772646 B1

PDFFull Text
Date of Patent:
Sep. 15, 2020

Filed:

May. 25, 2019

Method for controlling histotripsy using confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses

Applicant:

Xi'an Jiaotong University, Xi'an, Shaanxi, CN;

Inventors:

Mingzhu Lu, Shaanxi, CN;

Yizhe Geng, Shaanxi, CN;

Ruixin Li, Shaanxi, CN;

Xuan Wang, Shaanxi, CN;

Yanshan Liu, Shaanxi, CN;

Dan Han, Shaanxi, CN;

Yehui Liu, Shaanxi, CN;

Yujiao Li, Shaanxi, CN;

Rui Wang, Shaanxi, CN;

Mingxi Wan, Shaanxi, CN;

Assignee:

Xi'an Jiaotong University, Xi'an, CN;

Attorneys:

Wayne & Ken, LLC

Tony Hom

Primary Examiner:

Pascal M Bui Pho

Assistant Examiner:

Farouk A Bruce

Int. Cl.
CPC ...
A61B 17/22 (2006.01); A61N 7/00 (2006.01); A61B 17/00 (2006.01);
U.S. Cl.
CPC ...
A61B 17/22012 (2013.01); A61N 7/00 (2013.01); A61B 2017/00172 (2013.01); A61B 2017/22009 (2013.01); A61B 2017/22025 (2013.01); A61N 2007/0004 (2013.01); A61N 2007/0039 (2013.01); A61N 2007/0065 (2013.01); A61N 2007/0073 (2013.01);
Abstract

A method for controlling a histotripsy using a confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses, including: 1) positioning a target tissue by a monitoring and guiding system and adjusting a position of the target tissue to a focal point of a transducer; 2) first stage: controlling the confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses to form a shock wave in a focal zone; wherein a negative acoustic pressure exceeds a cavitation threshold; an inertial cavitation occurs to generate boiling bubbles; the boiling bubbles collapse and achieve partial homogenization of the target tissue; 3) second stage: controlling the confocal fundamental and harmonic superposition combined with hundred-microsecond pulsed-ultrasound sequences to simultaneously irradiate a target zone and further mechanically disintegrate and homogenize the target tissue.

Find Patent Forward Citations

Lu, Mingzhu. (2020). Method for controlling histotripsy using confocal fundamental and harmonic superposition combined with hundred-microsecond ultrasound pulses (U.S. Patent No. 10772646). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10772646

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