The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2020
Filed:
Jun. 03, 2019
Applicant:
Stemlab Inc., Seoul, KR;
Inventors:
Seung Kwon You, Yongin-si, KR;
Won Jin Yun, Gyeonggi-do, KR;
Min Ji Park, Busan, KR;
Ji Yong Park, Daegu, KR;
Assignee:
Stemlab Inc., Seoul, KR;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/079 (2010.01);
U.S. Cl.
CPC ...
C12N 5/0622 (2013.01); C12N 2501/065 (2013.01); C12N 2501/115 (2013.01); C12N 2501/135 (2013.01); C12N 2501/15 (2013.01); C12N 2501/235 (2013.01); C12N 2501/2306 (2013.01); C12N 2501/41 (2013.01); C12N 2501/603 (2013.01); C12N 2501/727 (2013.01); C12N 2501/999 (2013.01); C12N 2506/00 (2013.01); C12N 2506/1307 (2013.01);
Abstract
Provided is a method of inducing oligodendrocyte precursor cells (OPCs) through direct reprogramming from human somatic cells into which a nucleic acid molecule encoding an Oct4 protein or Oct4 protein-treated human somatic cells. The method of inducing OPCs by treating Oct4-overexpressing human somatic cells with a low molecular weight substance may establish OPCs with high efficiency in a short period of time through direct reprogramming without via neural stem cells, and thus the OPCs are useful as a cell therapeutic agent for an intractable demyelinating disease.