IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10767156 B1

PDFFull Text
Date of Patent:
Sep. 08, 2020

Filed:

Oct. 14, 2014

Polynucleotides encoding brex system polypeptides and methods of using same

Applicant:

Yeda Research and Development Co. Ltd., Rehovot, IL;

Inventors:

Rotem Sorek, Rohovot, IL;

Hila Sberro, Rehovot, IL;

Tamara Goldfarb, Rehovot, IL;

Assignee:

YEDA RESEARCH AND DEVELOPMENT CO., LTD., Rehovot, IL;

Attorneys:

Mark S. Cohen

Pearl Cohen

Zedek Latzer Baratz LLP

Primary Examiner:

Robert B Mondesi

Assistant Examiner:

Todd M Epstein

Int. Cl.
CPC ...
C12N 1/21 (2006.01); C12N 9/10 (2006.01); C12N 9/02 (2006.01); C12N 9/16 (2006.01); C12N 9/48 (2006.01); C12N 9/52 (2006.01); C07K 14/245 (2006.01); C07K 14/32 (2006.01); C07K 14/195 (2006.01); C12N 1/20 (2006.01); A23C 9/123 (2006.01); C12N 9/12 (2006.01); C12N 9/14 (2006.01); C12N 15/52 (2006.01);
U.S. Cl.
CPC ...
C12N 1/20 (2013.01); A23C 9/1234 (2013.01); C07K 14/195 (2013.01); C07K 14/245 (2013.01); C07K 14/32 (2013.01); C12N 9/0051 (2013.01); C12N 9/1007 (2013.01); C12N 9/12 (2013.01); C12N 9/14 (2013.01); C12N 9/16 (2013.01); C12N 9/48 (2013.01); C12N 15/52 (2013.01); C12Y 108/04008 (2013.01); C12Y 201/01072 (2013.01); C12Y 207/11001 (2013.01); C12Y 301/03001 (2013.01); C12Y 304/00 (2013.01); C12Y 306/04012 (2013.01); C12Y 306/04013 (2013.01); A23C 2220/202 (2013.01);
Abstract

Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHII, brxL, brxD, brxA, brxB, brxF, and brxE, with the proviso that said BREX system does not comprise pglW, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.

Find Patent Forward Citations

Loading…