The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2020
Filed:
Jun. 24, 2019
Applicant:
Omniox, Inc., San Carlos, CA (US);
Inventors:
Gregory Kapp, San Francisco, CA (US);
Laura Serwer, Brisbane, CA (US);
Natacha Le Moan, San Francisco, CA (US);
Stephen P. L. Cary, San Mateo, CA (US);
Assignee:
Omniox, Inc., San Carlos, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/41 (2006.01); C07K 14/795 (2006.01); A61K 38/16 (2006.01); A61K 45/06 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/795 (2013.01); A61K 38/164 (2013.01); A61K 38/41 (2013.01); A61K 45/06 (2013.01); A61K 38/00 (2013.01); C07K 2319/21 (2013.01);
Abstract
The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.