The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2020
Filed:
Sep. 20, 2018
Applicant:
Heptares Therapeutics Limited, Cambridge, GB;
Inventors:
Seyed Ali Jazayeri-Dezfuly, Hertfordshire, GB;
Fiona Hamilton Marshall, Hertfordshire, GB;
Assignee:
Heptares Therapeutics Limited, Cambridge, GB;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/72 (2006.01); C07K 14/705 (2006.01); G01N 33/566 (2006.01); C12N 9/36 (2006.01);
U.S. Cl.
CPC ...
C07K 14/723 (2013.01); C07K 14/705 (2013.01); C12N 9/2462 (2013.01); G01N 33/566 (2013.01); C07K 2319/00 (2013.01); C07K 2319/60 (2013.01);
Abstract
The invention provides a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a Family B G-protein coupled receptor (GPCR) that comprises transmembrane helix (TM)-1, TM2 and TM3 of the GPCR; b) a stable protein domain; and c) a second portion of the GPCR comprising TM4, TM5, TM6 and TM7 of the GPCR. The invention also provides a method of crystallising a GPCR comprising providing the fusion protein of the invention and crystallising it to obtain crystals.