The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2020
Filed:
Jan. 04, 2019
Amicogen, Inc., Gyeongsangnam-do, KR;
Yong Chul Shin, Gyeongsangnam-do, KR;
Zhe Piao, Gyeongsangnam-do, KR;
Su-Lim Choi, Gyeongsangnam-do, KR;
Yang Ho Jo, Gyeongsangnam-do, KR;
So-Young Park, Gyeongsangnam-do, KR;
Dae Beom Kwon, Gyeongsangnam-do, KR;
Amicogen, Inc., Gyeongsangnam-do, KR;
Abstract
The present invention relates to a mutated immunoglobulin-binding protein having increased alkaline tolerance and, more specifically, to an immunoglobulin-binding protein in which, with respect to the A-domain of Staphylococcal protein A, or a functional variant thereof, an amino acid at a specific site is mutated and thereby exhibits an increased chemical stability at an alkaline pH value in comparison to a parental molecule. The present invention can provide an antibody-purifying immunoglobulin-binding protein ligand and matrix which have enhanced alkaline tolerance and accordingly enhanced stability in multiple times of alkaline cleaning.