IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10766919 B1

PDFFull Text
Date of Patent:
Sep. 08, 2020

Filed:

Feb. 01, 2018

Cyclic di-nucleotide compounds as sting agonists

Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Michael D. Altman, Needham, MA (US);

Brian Andresen, Sharon, MA (US);

Wonsuk Chang, Princeton, NJ (US);

Matthew Lloyd Childers, Medfield, MA (US);

Jared N. Cumming, Winchester, MA (US);

Andrew Marc Haidle, Somerville, MA (US);

Timothy J. Henderson, Natick, MA (US);

James P. Jewell, Newton, MA (US);

Rui Liang, East Brunswick, NJ (US);

Jongwon Lim, Lexington, MA (US);

Hong Liu, Kenilworth, NJ (US);

Min Lu, Brookline, MA (US);

Alan B. Northrup, Belmont, CA (US);

Ryan D. Otte, Natick, MA (US);

Tony Siu, Brookline, MA (US);

Benjamin Wesley Trotter, Medfield, MA (US);

Quang T. Truong, Morganville, NJ (US);

Shawn P. Walsh, Bridgewater, NJ (US);

Kake Zhao, Westfield, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:

Julie M. Lake

Catherine D. Fitch

Primary Examiner:

Patrick T Lewis

Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); C07H 21/04 (2006.01); C07H 21/02 (2006.01); A61K 39/39 (2006.01); C07H 19/20 (2006.01); C07H 19/23 (2006.01); C07H 21/00 (2006.01); A61P 35/00 (2006.01); A61K 31/7064 (2006.01); A61K 31/7084 (2006.01); A61K 31/708 (2006.01); A61K 31/706 (2006.01); A61K 31/7076 (2006.01);
U.S. Cl.
CPC ...
C07H 21/04 (2013.01); A61K 39/39 (2013.01); A61P 35/00 (2018.01); C07H 19/20 (2013.01); C07H 19/23 (2013.01); C07H 21/00 (2013.01); C07H 21/02 (2013.01); A61K 31/706 (2013.01); A61K 31/708 (2013.01); A61K 31/7064 (2013.01); A61K 31/7076 (2013.01); A61K 31/7084 (2013.01);
Abstract

A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I″), wherein Base, Base, Y, Y, X, X, X, X, X, X, X, X, R, R, R, R, R, R, R, R, R, R, R, R, R, and Rare defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

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