The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 08, 2020

Filed:

Mar. 31, 2017
Applicants:

Ucb Biopharma Srl, Brussels, BE;

Sanofi, Paris, FR;

Inventors:

Teresa De Haro Garcia, Slough, GB;

Michael Louis Robert Deligny, Brussels, BE;

Jag Paul Heer, Slough, GB;

Helen Tracey Horsley, Slough, GB;

Sophie Jadot, Brussels, BE;

Jean Keyaerts, Brussels, BE;

Assignee:

UCB Biopharma SRL, Brussels, BE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/22 (2006.01); C07D 487/18 (2006.01); C07D 487/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/22 (2013.01); C07D 487/04 (2013.01); C07D 487/18 (2013.01);
Abstract

Disclosed are substituted fused hexacyclic benzimidazole derivatives of Formula (I) wherein the variables A, B, D, X, M, Q, n, p, q, Z, E, R, and Rare defined herein. These compounds are potent modulators of human TNFα activity and of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.


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