The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2020
Filed:
Jul. 09, 2019
Cystic Fibrosis Foundation, Bethesda, MD (US);
Joseph Walter Strohbach, Wentzville, MO (US);
David Christopher Limburg, Salem, CT (US);
John Paul Mathias, Concord, MA (US);
Atli Thorarensen, Stow, MA (US);
John James Mousseau, Norwich, CT (US);
Rajiah Aldrin Denny, Sharon, MA (US);
Christoph Wolfgang Zapf, Oakland, CA (US);
Ivan Viktorovich Efremov, Chestnut, MA (US);
Cystic Fibrosis Foundation, Bethesda, MD (US);
Abstract
The present invention relates to 5,7-disubstituted-imidazo[5,1-f][1,2,4]triazine-4-amine derivatives, and pharmaceutically acceptable salts thereof. The compounds are potentiators of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). The invention also discloses pharmaceutical compositions comprising the compounds, optionally in combination with additional therapeutic agents, and methods of potentiating, in mammals, including humans, CFTR by administration of the compounds. These compounds are useful for the treatment of cystic fibrosis (CF), asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD), constipation, Diabetes mellitus, dry eye disease, pancreatitis, rhinosinusitis, Sjögren's Syndrome, and other CFTR associated disorders.