The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2020
Filed:
Jun. 15, 2017
Chia Tai Tianqing Pharmaceutical Group Co., Ltd., Lianyungang, Jiangsu Province, CN;
Lianyungang Runzhong Pharmaceutical Co., Ltd., Lianyungang, Jiangsu Province, CN;
Centaurus Biopharma Co., Ltd., Beijing, CN;
Xiquan Zhang, Lianyungang, CN;
Aiming Zhang, Lianyungang, CN;
Zhou Zhou, Lianyungang, CN;
Huadong Yao, Lianyungang, CN;
Jie Xie, Lianyungang, CN;
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD., Lianyungang, Jiangsu, CN;
LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD., Lianyungang, Jiangsu, CN;
CENTAURUS BIOPHARMA CO., LTD., Beijing, CN;
Abstract
Provided are a preparation method for a chiral pyrrolopyrimidine compound and a related intermediate. In the method, a compound of formula A and a compound of formula 6 or a salt thereof are reacted to obtain a compound of formula 7 or a compound of formula 14, and a compound of formula I is prepared from the compound of formula 7 or the compound of formula 14. Also provided are the intermediate used, a preparation method for the intermediate and a use of the intermediate in the preparation of the compound of formula I. The preparation method has characteristics such as brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and a convenient post-treatment. The method avoids using an expensive asymmetric reaction catalyst, and is suitable for industrial production.