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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10766892 B1

PDFFull Text
Date of Patent:
Sep. 08, 2020

Filed:

May. 14, 2019

Gls1 inhibitors for treating disease

Applicant:

Board of Regents, the University of Texas System, Austin, TX (US);

Inventors:

Maria Emilia Di Francesco, Houston, TX (US);

Philip Jones, Houston, TX (US);

Timothy Heffernan, Sugar Land, TX (US);

Matthew M. Hamilton, Missouri City, TX (US);

Zhijun Kang, Richmond, TX (US);

Michael J. Soth, Sugar Land, TX (US);

Jason P. Burke, Houston, TX (US);

Kang Le, Sugar Land, TX (US);

Christopher Lawrence Carroll, Houston, TX (US);

Wylie S. Palmer, Houston, TX (US);

Richard Lewis, Missouri City, TX (US);

Timothy McAfoos, Pearland, TX (US);

Barbara Czako, Bellaire, TX (US);

Gang Liu, Sugar Land, TX (US);

Jay Theroff, Manvel, TX (US);

Zachary Herrera, El Cerrito, CA (US);

Anne Yau, Houston, TX (US);

Assignee:

Board of Regents, The University of Texas System, Austin, TX (US);

Attorneys:

Dennis A. Bennett

Cynthia Hathaway

John Desper

Primary Examiner:

John M Mauro

Int. Cl.
CPC ...
C07D 417/14 (2006.01); A61K 31/4439 (2006.01); A61K 45/06 (2006.01); C07D 417/06 (2006.01); A61K 31/433 (2006.01); C07D 403/06 (2006.01); A61K 31/501 (2006.01); C07D 401/14 (2006.01); A61K 31/454 (2006.01); A61K 31/4192 (2006.01); C07D 405/14 (2006.01); C07D 403/14 (2006.01); A61K 31/444 (2006.01); C07D 493/08 (2006.01); A61K 31/497 (2006.01);
U.S. Cl.
CPC ...
C07D 417/14 (2013.01); A61K 31/4192 (2013.01); A61K 31/433 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/497 (2013.01); A61K 31/501 (2013.01); A61K 45/06 (2013.01); C07D 401/14 (2013.01); C07D 403/06 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 417/06 (2013.01); C07D 493/08 (2013.01);
Abstract

Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

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