The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 08, 2020

Filed:

Jul. 13, 2015
Applicants:

Matthew Becker, Stow, OH (US);

Wen Tang, Akron, OH (US);

Inventors:

Matthew Becker, Stow, OH (US);

Wen Tang, Akron, OH (US);

Assignee:

University of Akron, Akron, OH (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/10 (2017.01); C07K 14/51 (2006.01); C07K 7/08 (2006.01);
U.S. Cl.
CPC ...
A61K 47/10 (2013.01); C07K 7/08 (2013.01); C07K 14/51 (2013.01);
Abstract

In various aspects, embodiments of the present invention are directed to a series of multivalent dendrons containing a bioactive peptide domain and surface-binding catechol domains. In some embodiments, these multivalent dendrons were obtained through solid phase synthesis and have a strong binding affinity to metal oxide surfaces such as, TiO, ZrO, CeO, and FeO, SiO2, as well as other inorganic surfaces such as hydroxyapatite, silver, fluorapatite, calcium carbonate and gold. These catechol-bearing dendrons provide a fast and efficient method to functionalize a wide range of inorganic materials with bioactive peptides and have the potential to be used in coating orthopaedic implants and fixation devices.


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