The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2020
Filed:
Nov. 20, 2017
Alderbio Holdings Llc, Las Vegas, NV (US);
The University of Iowa Research Foundation, Iowa City, IA (US);
Andrew F. Russo, Iowa City, IA (US);
Eric A. Kaiser, Iowa City, IA (US);
Ana Recober, Iowa City, IA (US);
Adisa Kuburas, Iowa City, IA (US);
Ann C. Raddant, Iowa City, IA (US);
Brian R. Kovacevich, Snohomish, WA (US);
John Latham, Seattle, WA (US);
Jeffrey T. L. Smith, Bellevue, WA (US);
Leon F. Garcia-Martinez, Woodinville, WA (US);
ALDERBIO HOLDINGS LLC, Las Vegas, NV (US);
THE UNIVERSITY OF IOWA RESEARCH FOUNDATION, Iowa City, IA (US);
Abstract
The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for CGRP. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated CGRP levels, e.g., in the GI tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. More specifically, this invention relates to treatments using the anti-CGRP antibodies and fragments described herein, and binding fragments thereof.