The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 08, 2020
Filed:
Jul. 07, 2016
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health & Human Services, Rockville, MD (US);
Inventors:
Bira Arya, Elliott City, MD (US);
Purevdorj Olkhanud, Baltimore, MD (US);
Juan Espinoza, Los Angeles, CA (US);
Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 31/713 (2006.01); C12N 15/87 (2006.01); A61K 47/64 (2017.01); C07K 14/005 (2006.01); C07K 14/52 (2006.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 47/642 (2017.08); A61K 47/6455 (2017.08); C07K 14/005 (2013.01); C07K 14/523 (2013.01); C12N 15/87 (2013.01); C07K 2319/33 (2013.01); C07K 2319/74 (2013.01); C07K 2319/85 (2013.01);
Abstract
The present invention features compositions and methods that make use of complexes comprising one or more inhibitory nucleic acids and a targeting polypeptide, wherein the targeting polypeptide consists of a cell surface receptor ligand. The compositions can be used in methods of silencing gene expression in a cell, delivering agents to a target cell, and in treating or preventing a disease or disorder in a subject.