The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Nov. 30, 2017
Applicant:
Oregon Health & Science University, Portland, OR (US);
Inventors:
Assignee:
OREGON HEALTH & SCIENCE UNIVERSITY, Portland, OR (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 39/12 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 39/12 (2013.01); C12N 7/00 (2013.01); A61K 2039/5256 (2013.01); C12N 2710/16121 (2013.01); C12N 2710/16143 (2013.01); C12N 2740/15034 (2013.01); C12N 2740/15071 (2013.01); C12N 2800/204 (2013.01); Y02A 50/386 (2018.01); Y02A 50/388 (2018.01); Y02A 50/394 (2018.01); Y02A 50/412 (2018.01); Y02A 50/466 (2018.01);
Abstract
Disclosed herein are recombinant CMV vectors which may comprise a heterologous antigen that can repeatedly infect an organism while inducing a CD8+ T cell response to immunodominant epitopes of the heterologous antigen. The CMV vector may comprise a deleterious mutation in the US11 glycoprotein or a homolog thereof.