The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Jul. 20, 2017
Applicant:
Qgel SA, Lausanne, CH;
Inventors:
Simone Rizzi, Ecublens, CH;
Jeremy Touati, Sottens, CH;
Assignee:
QGEL SA, Lausanne, CH;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/74 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/6429 (2013.01); C12N 5/0018 (2013.01); C12N 5/0068 (2013.01); C12N 2523/00 (2013.01); C12N 2533/30 (2013.01); C12N 2533/50 (2013.01); C12N 2537/10 (2013.01); C12Y 203/02013 (2013.01); C12Y 304/21005 (2013.01);
Abstract
A hydrogel precursor formulation which is in the form of an unreacted powder. The formulation comprises an activating enzyme, preferably thrombin, a cross-linking enzyme, preferably a transglutaminase, and more preferably factor XIII transglutaminase. The cross-linking enzyme is activatable by the activating enzyme in water with or without a buffer, and at least one structural compound A. The structural compound is crosslinkable by a selective reaction mediated by the crosslinking enzyme to form a hydrogel, wherein the cross-linking enzyme is activated.