The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Sep. 03, 2014
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Timothy Kuan-Ta Lu, Charlestown, MA (US);
Robert James Citorik, Kingston, NH (US);
Mark Kyle Mimee, Cambridge, MA (US);
Assignee:
Massachusetts Institute of Technology, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/22 (2006.01); A61K 38/46 (2006.01); C12N 15/74 (2006.01);
U.S. Cl.
CPC ...
C12N 9/22 (2013.01); A61K 38/465 (2013.01); C12N 15/74 (2013.01);
Abstract
Various aspects and embodiments of the invention are directed to methods and compositions for reversing antibiotic resistance or virulence in and/or destroying pathogenic microbial cells such as, for example, pathogenic bacterial cells. The methods include exposing microbial cells to a delivery vehicle with at least one nucleic acid encoding an engineered autonomously distributed circuit that contains a programmable nuclease targeted to one or multiple genes of interest.