The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Jul. 06, 2012
Applicants:
Paul Parren, Odijk, NL;
Frank Beurskens, Culemborg, NL;
Rob N. DE Jong, Driebergen-Rijsenburg, NL;
Aran Frank Labrijn, Nigtevecht, NL;
Janine Schuurman, Diemen, NL;
Inventors:
Paul Parren, Odijk, NL;
Frank Beurskens, Culemborg, NL;
Rob N. De Jong, Driebergen-Rijsenburg, NL;
Aran Frank Labrijn, Nigtevecht, NL;
Janine Schuurman, Diemen, NL;
Assignee:
GENMAB B.V., Utrecht, NL;
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); C12N 15/00 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C07K 16/36 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); C07K 16/00 (2013.01); C07K 16/2863 (2013.01); C07K 16/2887 (2013.01); C07K 16/36 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/34 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/77 (2013.01); C07K 2317/90 (2013.01); C07K 2317/92 (2013.01);
Abstract
Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.