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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10759863 B1

PDFFull Text
Date of Patent:
Sep. 01, 2020

Filed:

Sep. 04, 2014

Modulation of γδ t cells

Applicant:

Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US);

Inventors:

Carl F. Ware, La Jolla, CA (US);

John R. Sedy, La Jolla, CA (US);

Assignee:

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, La Jolla, CA (US);

Attorney:

Wilson Sonsini Goodrich & Rosati

Primary Examiner:

Bridget E Bunner

Int. Cl.
CPC ...
A61K 31/7088 (2006.01); A61K 31/7105 (2006.01); A61K 38/20 (2006.01); C12N 15/113 (2010.01); C07K 16/28 (2006.01); G01N 33/50 (2006.01); A61K 45/06 (2006.01); A61K 31/00 (2006.01); C07K 14/54 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2878 (2013.01); A61K 31/00 (2013.01); A61K 31/7088 (2013.01); A61K 31/7105 (2013.01); A61K 38/2046 (2013.01); A61K 45/06 (2013.01); C12N 15/113 (2013.01); C12N 15/1138 (2013.01); G01N 33/505 (2013.01); A61K 2039/505 (2013.01); C07K 14/5418 (2013.01); C07K 2317/75 (2013.01); C12N 2310/14 (2013.01);
Abstract

The present invention relate to the discovery that BTLA, IL-7 and RORγt modulate the activity and expression of γδT cells. Specifically, the present invention provides methods of modulating γδT cell homeostasis and function by regulating expression of BTLA. The present invention further provides agents which modulate the activity and expression of BTLA, RORyt and IL-7 and methods for screening of such agents. The present invention also provides methods for treating autoimmune or inflammatory diseases using modulators of BTLA, RORyt and IL-7.

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