The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Oct. 11, 2019
Medimmune, Llc, Gaithersburg, MD (US);
Brett R. Sellman, Gaithersburg, MD (US);
Christine Tkaczyk, Gaithersburg, MD (US);
Melissa Hamilton, Gaithersburg, MD (US);
Lei Hua, Gaithersburg, MD (US);
MEDIMMUNE, LLC, Gaithersburg, MD (US);
Abstract
The present invention provides for methods of preventing and/or treating-associated bacteremia and sepsis, and methods for preventing and/or treating-associated pneumonia in immunocompromised patients using anti-alpha-toxin (anti-AT) antibodies. Also provided are methods of reducingbacterial load in the bloodstream or heart of a mammalian subject comprising administering to the subject an effective amount of an isolated anti-alpha toxin (anti-AT) antibody or antigen-binding fragment thereof. Methods of reducingbacterial agglutination and/or thromboembolic lesion formation in a mammalian subject comprising administering to the subject an effective amount of an isolated anti-alpha toxin (anti-AT) antibody or antigen-binding fragment thereof, are also provided. Also provided are methods of preventing or reducing the severity ofassociated pneumonia in an immunocompromised mammalian subject.