The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Mar. 15, 2017
Applicants:
Purdue Research Foundation, West Lafayette, IN (US);
National Institutes of Health, Bethesda, MD (US);
Inventors:
Mark S. Cushman, West Lafayette, IN (US);
Daniel E. Beck, West Palm Beach, FL (US);
Yves Pommier, Bethesda, MD (US);
Assignees:
PURDUE RESEARCH FOUNDATION, West Lafayette, IN (US);
UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES, Bethesda, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/435 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01);
Abstract
The invention described herein pertains to four series of aza-A-ring indenoisoquinolines, which are inhibitors of topoisomerase IB (Top1), and the processes for preparing said aza-A-ring indenoisoquinolines. Also described are methods for treating cancer in mammals using the described aza-A-ring indenoisoquinoline compounds or pharmaceutical formulations thereof.