The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 01, 2020

Filed:

Apr. 07, 2017
Applicant:

Northwestern University, Evanston, IL (US);

Inventors:

Richard B. Silverman, Winnetka, IL (US);

Heng-Yen Wang, Kaohsiung, TW;

Yajuan Qin, Nanjing, CN;

Fengwei Zou, Evanston, IL (US);

Soo Sung Kang, Evanston, IL (US);

Qing Jing, Evanston, IL (US);

Assignee:

Northwestern University, Evanston, IL (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/44 (2006.01); C07D 471/04 (2006.01); C07D 401/14 (2006.01); A61K 31/444 (2006.01); C07D 213/73 (2006.01); C07D 213/74 (2006.01); C07D 401/04 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61K 45/06 (2006.01); C07D 401/10 (2006.01); C07D 401/12 (2006.01); C07D 401/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/44 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); C07D 213/73 (2013.01); C07D 213/74 (2013.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01);
Abstract

Disclosed are compounds that are shown to inhibit the biological activity of nitric oxide synthases (NOSs). Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject in need thereof. Because the disclosed compounds are shown to inhibit the activity of nitric oxide synthases (NOSs), the disclosed compounds and pharmaceutical compositions may be utilized in methods for treating a subject having or at risk for developing a disease or disorder that is associated with NOS activity.


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