The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 01, 2020

Filed:

Oct. 27, 2017
Applicant:

Biocryst Pharmaceuticals, Inc., Durham, NC (US);

Inventors:

Pravin L. Kotian, Hoover, AL (US);

Yarlagadda S. Babu, Birmingham, AL (US);

V. Satish Kumar, Birmingham, AL (US);

Venkat R. Chintareddy, Vestavia Hills, AL (US);

Weihe Zhang, Vestavia, AL (US);

Lakshminarayana Vogeti, Lawrence, KS (US);

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/81 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 413/12 (2006.01); C07D 495/04 (2006.01);
U.S. Cl.
CPC ...
C07D 213/81 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 413/12 (2013.01); C07D 495/04 (2013.01);
Abstract

Disclosed are compounds of formula I, II, and III, and pharmaceutically acceptable salts thereof, which are inhibitors of kallikrein. Also provided are pharmaceutical compositions comprising such a compound, and methods involving use of the compounds and compositions in the treatment and prevention of acquired or hereditary angioedema, or other diseases and conditions characterized by aberrant kallikrein activity.


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