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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10759743 B1

PDFFull Text
Date of Patent:
Sep. 01, 2020

Filed:

Oct. 19, 2017

Pd-catalyzed γ-c(sp)-h arylation / heteroarylation of free amines

Applicant:

The Scripps Research Institute, La Jolla, CA (US);

Inventor:

Jin-Quan Yu, San Diego, CA (US);

Assignee:

THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);

Attorney:

Schwegman Lundberg & Woessner, P.A.

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
C07C 211/35 (2006.01); C07C 211/03 (2006.01); C07C 269/04 (2006.01); C07D 215/12 (2006.01); C07C 209/68 (2006.01); C07D 213/40 (2006.01); C07D 213/61 (2006.01); C07B 37/04 (2006.01); B01J 31/22 (2006.01); C07D 213/64 (2006.01); C07D 241/42 (2006.01); C07D 319/18 (2006.01); C07D 333/22 (2006.01); C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07C 269/04 (2013.01); B01J 31/2239 (2013.01); C07B 37/04 (2013.01); C07C 209/68 (2013.01); C07D 213/40 (2013.01); C07D 213/61 (2013.01); C07D 213/64 (2013.01); C07D 215/12 (2013.01); C07D 241/42 (2013.01); C07D 319/18 (2013.01); C07D 333/22 (2013.01); C07D 471/04 (2013.01); B01J 2231/44 (2013.01); B01J 2531/824 (2013.01); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2601/18 (2017.05);
Abstract

Pd(II)-catalyzed g-G(sp3)-H arylation or heteroarylation of primary amines is realized by using 2-hydroxynicotinaldehyde as a catalytic transient directing group. Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% respectively, thus demonstrating high efficiency of this newly designed transient directing group. Heterocyclic aryl iodides are also compatible with this reaction. Furthermore, swift synthesis of 1,2,3,4-tetrahydronaphthyridine derivatives is accomplished using this reaction.

Find Patent Forward Citations

Yu, Jin-Quan. (2020). Pd-catalyzed γ-c(sp)-h arylation / heteroarylation of free amines (U.S. Patent No. 10759743). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10759743

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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