The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 01, 2020
Filed:
Jan. 11, 2019
Florida Atlantic University Board of Trustees, Boca Raton, FL (US);
Salvatore D. Lepore, Delray Beach, FL (US);
Kenneth Dawson-Scully, Boca Raton, FL (US);
Elijah J. St. Germain, Davie, FL (US);
Samantha L. Maki, Delray Beach, FL (US);
Wesley L. Bollinger, Dallas, TX (US);
Nadia K. Sial, Boca Raton, FL (US);
Florida Atlantic University Board of Trustees, Boca Raton, FL (US);
Abstract
Neuroprotective compounds for reducing neurological damage due to cellular stress in an individual are of Formula 1: or an enantiomer, diastereomer, racemic mixture or a pharmaceutically acceptable salt thereof, wherein: Ar=aryl; Y=aryl substituent (ortho, meta, or para) selected from the group consisting of: alkyl, alkyloxy, alkylamino, RRN, and halo; X═O, N, or S; R═H, alkyl, aryl, OH, alkyloxy, aryloxy, NH, alkylamino, RRN, or arylamino; Rand R=alkylcarbonyl, arylcarbonyl, alkyl, or H, individually; R=arylCH═CH, alkylCH═CH, alkyl; R═H, alkyl, or aryl; and Rand R=alkyl, individually. Methods of reducing neurological damage due to cellular stress in an individual include administering to the individual during or after the cellular stress a neuroprotective compound of Formula I in a therapeutically effective amount to restore synaptic function during or after the cellular stress.