The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 01, 2020

Filed:

Apr. 14, 2016
Applicant:

Benhealth Biopharmaceutic (Shenzhen) Co., Ltd., Shenzhen, CN;

Inventors:

Haoyang Yu, Shenzhen, CN;

Zhengcheng Li, Shenzhen, CN;

Jing Su, Shenzhen, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/59 (2017.01); A61K 39/44 (2006.01); A61K 47/68 (2017.01); C07K 16/30 (2006.01); A61K 47/69 (2017.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/593 (2017.08); A61K 39/44 (2013.01); A61K 47/6849 (2017.08); A61K 47/6851 (2017.08); A61K 47/6935 (2017.08); A61K 47/6937 (2017.08); C07K 16/2803 (2013.01); C07K 16/2809 (2013.01); C07K 16/2815 (2013.01); C07K 16/2887 (2013.01); C07K 16/3069 (2013.01); C07K 16/3092 (2013.01); C07K 16/32 (2013.01); A61K 2039/505 (2013.01); A61K 2039/507 (2013.01); C07K 2317/31 (2013.01); C07K 2317/73 (2013.01);
Abstract

The present invention provides a bispecific antibody capable of being combined with immune cells to enhance a targeting tumor killing capability, and a preparation method therefor and an application thereof. Antibodies and degradable nanoparticles are connected by using a chemical method, so as to make the one nanoparticle be connected to two or more antibody molecules at the same time, wherein one antibody can be specifically bound with immune cells, and the other antibody or the other antibodies can be specifically bound to tumor cells so as to achieve the effect of enhancing the capability of the immune cells for specifically killing tumor cells in a targeting way.


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