logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10758624 B1

PDFFull Text
Date of Patent:
Sep. 01, 2020

Filed:

Jun. 30, 2016

Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof

Applicant:

City of Hope, Duarte, CA (US);

Inventors:

Marcin Tomasz Kortylewski, Monrovia, CA (US);

Piotr Marek Swiderski, San Dimas, CA (US);

Dayson Friaca Moreira, Duarte, CA (US);

Assignee:

CITY OF HOPE, Duarte, CA (US);

Attorney:

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

Primary Examiner:

Tracy Vivlemore

Int. Cl.
CPC ...
A61K 31/713 (2006.01); C12N 15/113 (2010.01); A61K 47/54 (2017.01); A61K 45/06 (2006.01); A61P 37/00 (2006.01); A61P 35/02 (2006.01); A61P 35/00 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/549 (2017.08); A61K 31/713 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61P 35/02 (2018.01); A61P 37/00 (2018.01); C12N 15/113 (2013.01); C12N 15/1135 (2013.01); A61K 48/00 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3519 (2013.01); C12N 2320/30 (2013.01); C12N 2320/31 (2013.01); C12N 2320/35 (2013.01); C12N 2320/51 (2013.01);
Abstract

The present disclosure relates to an isolated compound including a phosphorothioated oligodeoxynucleotide (ODN) sequence conjugated to a short-activating RNA (saRNA) or an antisense oligonucleotide sequence (ASO), compositions of such a compound, and method of treatment of cancer and autoimmune diseases (with or without stimulating immune response), method of immune stimulation, method of activating CEBPA, and method of reducing activity of STAT transcription factor, by one of the disclosed compounds or compositions.

Find Patent Forward Citations

Kortylewski, Marcin. (2020). Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof (U.S. Patent No. 10758624). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10758624

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…